1·The team suffered a major setback when their best player was injured.
最优秀的队员受了伤，使得这支队伍的实力大打折扣。
—— 《牛津词典》
2·What have you faced a major setback in your work?
你在工作中碰到过什么样的挫折？
3·What have you faced a major setback in your work?
你在工作中遇到过什么样的挫折？
4·First, has the candidate faced a crisis or overcome a major setback in his or her life?
首先，这位候选人一生中有没有遇到过危机呢？或者有没有克服过人生的重大挫折呢？
5·These events are a major setback to the establishment of a peaceful settlement of the conflict.
这些事件对以和平方式解决冲突来说是一次重大挫折。
6·The security breach was a major setback to the CIA, which has been expanding its presence in Afghanistan.
对于正在扩大在阿富汗的存在的中情局来说，这次暴露了安全隐患的事件是一个巨大的后退。
7·A major setback is that applications built this way can't access native iPhone features like accelerometer, GPS, camera, contacts, etc.
一个主要缺陷是用这种方法创建的应用程序不能获得本机iPhone的功能，例如加速器、GPS、照相机、通讯录等。
8·Regional commander Major-General Sajjad Ghani says the capture of Banai Baba Ziarat was a major setback for the militants and has paved the way for gains on the battlefield.
地区指挥官加尼少将说，收复加拉特山脊是对激进分子的重大挫败，为赢得战场胜利铺平了道路。
9·However, such relief is in effect a major setback for European integration. Such setbacks don't happen in good times. Britain's exit reflects the general decline of Europe.
然而这种解脱当然是欧洲一体化进程的重大倒退。当欧盟的事业一帆风顺时，这种倒退不可能发生。英国脱欧说到底是欧洲衰落的体现。
10·At one point he suffered a setback at work and I worried that he was headed for a major depression.
有一次他在工作上受到了挫折，我又开始担心他会不会一蹶不振。